We get asked this a lot, and it’s a fair question. The good news is that pharmaceutical-grade polynucleotides have an excellent safety record. The purification process removes the proteins that could cause allergic reactions, making them suitable even for our most sensitive patients. Side effects are usually minimal – a bit of redness, some small bumps where we’ve injected, and possibly light bruising. All of this settles quickly. Your body naturally breaks down the DNA fragments over time, so there’s nothing foreign left behind. Severe reactions are incredibly rare, but we always take a thorough medical history and might do a small test patch if you’re particularly sensitive. The key is using genuine, medical-grade products from reputable manufacturers – which is exactly what we do.

For the best results, we typically recommend starting with 3 treatments, spaced 3–4 weeks apart. This initial course allows for progressive cellular activation and regeneration. Some lucky patients see improvements after just one session, but the full effects develop over the complete treatment course. After your initial series, maintenance treatments every 6-9 months help keep the results going. The exact schedule depends on your age, skin condition, and what you’re hoping to achieve. Younger patients with decent skin might get away with fewer sessions, while more mature skin often benefits from additional treatments. During your consultation, we’ll assess your skin properly and create a realistic treatment plan. Most patients find the results get better with each session as cellular function improves.

Yes, polynucleotides can be brilliant for improving acne scarring. They work by stimulating your fibroblasts to produce new collagen, which helps fill in depressed scars from within. The anti-inflammatory properties also help calm any ongoing acne activity. For best results with scarring, we often combine polynucleotides with other treatments like microneedling or chemical peels. The polynucleotides enhance your skin’s healing response, making these other treatments work even better. You’ll typically start seeing improvements in scar appearance after 2-3 treatments, with continued enhancement over several months. While very deep scars might not disappear completely, most patients see significant improvement in texture and overall skin quality. It’s quite rewarding to see the transformation.

One of the things our patients love about polynucleotides is the minimal downtime. Right after treatment, you’ll have small bumps at the injection sites – they look a bit like mosquito bites but flatten within 24-48 hours. Some people get mild swelling, especially around the eyes, but this settles quickly too. Most people go straight back to their normal activities, though we suggest avoiding makeup for 24 hours and heavy exercise for 48 hours. Sun protection is crucial while your skin is regenerating. We’ll give you specific aftercare products and detailed instructions. Unlike some treatments, you won’t peel or have visible shedding – all the regeneration happens beneath the surface. Most patients find it much easier to manage than aggressive peels or laser treatments, while still getting profound improvements in skin quality.